Abstract: Gas control methods based on drainage will make mine gas discharge into the atmosphere, resulting in environmental pollution and aggravating the greenhouse effect. Using microbial technology to degrade mine gas can eliminate mine gas fundamentally and reduce the harm of gas to mine safety and environment. This paper summarizes and analyzes the research results of microbial treatment technology of mine gas, analyzes the feasibility of microbial treatment of mine gas from the aspects of microbial gas degradation mechanism, degradation products, mining microbial culture, application mode and field application effect, and prospects its development trend. The existing technology of microbial degradation gas has some technical bottlenecks, such as single bacteria species, poor adaptability to underground environment, small injection and diffusion range of coal seam, etc. Solving these key technical problemes will become the development direction of microbial treatment of mine gas technology.